Characterization of Canine Caspase-3

Characterization of Social Behaviors in caspase-3 deficient mice

Impaired social interaction is a defining feature of autism spectrum disorder, a neurodevelopmental disorder that shows a strong male preponderance in prevalence. Studies have identified neural circuits, neuromodulators and genetic factors involved in social behaviors, but mechanistic understanding of gender-specific social deficits is lacking. We report that deletion of the caspase-3 gene, enc...

overy and Canine Preclinical Assessment of a Nontoxic R caspase-3–Activating Compound

r Res; 70( ritical event in the apoptotic cascade is the proteolytic activation of procaspases to active caspases. spase autoactivating compound PAC-1 induces cancer cell apoptosis and exhibits antitumor activity rine xenograft models when administered orally as a lipid-based formulation or implanted s.c. as a terol pellet. However, high doses of PAC-1 were found to induce neurotoxicity, prompt...

Genotypic Characterization of Canine Coronaviruses

Characterization of canine neutrophil granules.

The purpose of this study was to isolate distinct populations of canine neutrophil granules and to compare them with neutrophil granules from other species. Size, shape, density, and content of canine neutrophil granules were determined. Neutrophils obtained by Ficoll-Hypaque sedimentation were homogenized, and granule populations were separated by isopycnic centrifugation on a linear sucrose g...

Characterization of Iranian Isolates of Canine Parvovirus in Fecal Samples Using Polymerase Chain Reaction Assay

Despite the widespread prevalence of canine parvovirus disease (CPV) in Iranian dog population,molecular diagnosis of CPV variants, and investigation of the trends of its genetic changes is a new effort. Inthis study 50 samples from dogs suspicious of infection with clinical signs of diarrhea and vomiting, and 25samples from dogs suspected of infection with general symptoms su...